Issue 15, 2022

Iron-catalyzed one-pot cyclization and amination of 2-alkynylthioanisoles using nitrosobenzenes as the amine source

Abstract

A direct strategy for the synthesis of 3-phenylaminobenzothiophene via iron-catalyzed cyclization of 2-alkynylthioanisoles and nitrosoarenes is presented in this work. This method realizes the construction and amination of the benzothiophene ring in which nitrosoarenes serve as the amine source. Various functional groups are tolerated in this reaction and the desired products are obtained in moderate yields.

Graphical abstract: Iron-catalyzed one-pot cyclization and amination of 2-alkynylthioanisoles using nitrosobenzenes as the amine source

Supplementary files

Article information

Article type
Research Article
Submitted
01 Apr 2022
Accepted
19 Jun 2022
First published
21 Jun 2022

Org. Chem. Front., 2022,9, 4085-4090

Iron-catalyzed one-pot cyclization and amination of 2-alkynylthioanisoles using nitrosobenzenes as the amine source

Y. Ren, Z. An, P. Zhao, M. Li and R. Yan, Org. Chem. Front., 2022, 9, 4085 DOI: 10.1039/D2QO00535B

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