Copper-catalyzed direct monofluoroalkenylation of C(sp3)–H bonds via decarboxylation of α-fluoroacrylic acids

Abstract

Herein, a protocol for the copper-catalyzed direct monofluoroalkenylation of C(sp³)–H bonds is reported. A wide range of α-fluoroacrylic acids and C–H patterns were suitable reaction substrates, delivering the corresponding monofluoroalkenes with excellent Z-stereoselectivity. These are vital structural motifs in synthetic organic chemistry and pharmaceutical sciences. In addition to α-fluoroacrylic acids, β-fluoroacrylic acids were also compatible reaction substrates.