Visible-light-initiated regio- and stereoselective C(sp2)–H phosphorylation of enamides under transition-metal-free conditions

Ji-Yu Tao; Qing-Hong Zhang; Tong-Hao Zhu; Xin-Wen Xu; Kun Ni; Qiao Zhao; Zheng-Bao Qin; Yu Zhang; Lili Zhao; Kai Zhao

doi:10.1039/D2QO01304E

Visible-light-initiated regio- and stereoselective C(sp²)–H phosphorylation of enamides under transition-metal-free conditions†

Ji-Yu Tao,‡^a Qing-Hong Zhang,‡^a Tong-Hao Zhu,‡^ad Xin-Wen Xu,‡^a Kun Ni,^a Qiao Zhao,^a Zheng-Bao Qin,^a Yu Zhang,

^b Lili Zhao

^a and Kai Zhao

*^ac

Author affiliations

* Corresponding authors

^a Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China
E-mail: ias_kzhao@njtech.edu.cn

^b College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

^c Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China

^d Institute of Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, China

Abstract

A visible-light-induced stereo- and regioselective phosphorylation reaction of enamides with phosphine oxides has been disclosed, delivering synthetically and pharmaceutically appealing β-phosphorylated enamides with broad substrate scopes and excellent functional group tolerance under transition-metal-free conditions.

Organic Chemistry Frontiers

Visible-light-initiated regio- and stereoselective C(sp²)–H phosphorylation of enamides under transition-metal-free conditions†

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Visible-light-initiated regio- and stereoselective C(sp²)–H phosphorylation of enamides under transition-metal-free conditions

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