Issue 11, 2022
From the journal:

RSC Advances

Synthesis of dihydroisoquinolinone-4-methylboronic esters via domino Heck/borylation using a structurally characterized palladacycle as a catalyst †

Jhansi Rani Morlaa  and  Dastagiri Reddy Nareddula ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Pondicherry University, Pondicherry 605014, India
E-mail: ndreddy.che@pondiuni.edu.in

Abstract

Synthesis of dihydroisoquinolinone-4-methylboronic esters from N-allylcarboxamides and B2(Pin)2 via domino Heck/borylation approach is reported. A quinoxaline-based NHC-palladacycle [Pd(C∧C:)PPh3Cl], which has been structurally characterized, is used as a catalyst. The scope of the substrate with a wide range of substituents is explored. In addition to the synthesis of title compounds, a few examples of methylboronic esters of indoline and benzofuran motifs have also been prepared using the same protocol.

Graphical abstract: Synthesis of dihydroisoquinolinone-4-methylboronic esters via domino Heck/borylation using a structurally characterized palladacycle as a catalyst

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Article information

DOI
https://doi.org/10.1039/D2RA00389A
Article type
Paper
Submitted
19 Jan 2022
Accepted
14 Feb 2022
First published
28 Feb 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 6762-6771

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Synthesis of dihydroisoquinolinone-4-methylboronic esters via domino Heck/borylation using a structurally characterized palladacycle as a catalyst

J. R. Morla and D. R. Nareddula, RSC Adv., 2022, 12, 6762 DOI: 10.1039/D2RA00389A

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