Issue 48, 2022, Issue in Progress

Precisely controlling the cellular internalization of DNA-decorated semiconductor polymer nanoparticles for drug delivery

Abstract

Nonspecific adhesivity of nanoparticles to cells is regarded as a significant issue of nanomedicine, which brings about many serious drawbacks in applications, including low detection sensitivity, non-targeted biotoxicity and poor diagnostic accuracy. Here, we propose for the first time, DNA-decorated semiconductor polymer nanoparticles (SPN-DNAs), whose adhesivity can be significantly alleviated by controlling the density and thickness of DNA layers. This property is demonstrated to be independent of external conditions such as temperature, concentration, incubation time, ionic strength and cell lines. The mechanism of this phenomenon is also discussed. Finally, based on minimized nonspecific adhesivity to cells, a triggered nanoswitch can be constructed to control cellular internalization and drug delivery.

Graphical abstract: Precisely controlling the cellular internalization of DNA-decorated semiconductor polymer nanoparticles for drug delivery

Supplementary files

Article information

Article type
Paper
Submitted
18 Aug 2022
Accepted
04 Oct 2022
First published
01 Nov 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 31173-31179

Precisely controlling the cellular internalization of DNA-decorated semiconductor polymer nanoparticles for drug delivery

Y. Tan, M. Xiong, Q. Liu, Y. Yin, X. Yin, S. Liao, Y. Wang, L. Hu and X. Zhang, RSC Adv., 2022, 12, 31173 DOI: 10.1039/D2RA05172A

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