Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.
K. Yang, J. E. Boles, L. J. White, K. L. F. Hilton, H. Y. Lai, Y. Long, J. R. Hiscock and C. J. E. Haynes, RSC Adv., 2022, 12, 27877 DOI: 10.1039/D2RA05314D
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