Issue 13, 2023

Stealth-like polysarcosine-modified nanoparticles with low dye doses and long blood circulation for efficient breast cancer pulmonary metastasis imaging

Abstract

Fluorescence imaging (FLI) in the near-infrared-II (NIR-II; 1000–1700 nm) window holds great potential for cancer metastasis imaging owing to its deep tissue penetration and a high signal-to-background ratio. However, currently reported organic NIR-II contrast agents generally present problems such as poor water solubility, low NIR-II fluorescence quantum yield (QY), short blood circulation half-life (t1/2), high injection doses, and undesirable tumor accumulation. In this study, an NIR-II small-molecule-based polymer (TQF–PSar) modified with four dense/hydrophilic polysarcosine (PSar) arms was prepared for efficient breast cancer pulmonary metastasis imaging. The NIR-II intensity of TQF–PSar (whose QY was calculated to be 1%) was 26.4-fold higher than that of the PEGylated nanoparticles (TQF–PEG NPs) at the same low dye dose (core TQF concentration: 2.5 μg mL−1). Moreover, owing to the ideal stealth character, TQF–PSar displayed a more prolonged blood circulation t1/2 (36.9 h) and better tumor accumulation capability than TQF–PEG NPs even at this low dye concentration. Finally, the successful use of TQF–PSar in noninvasive NIR-II FLI for breast cancer pulmonary metastasis was demonstrated in living mice.

Graphical abstract: Stealth-like polysarcosine-modified nanoparticles with low dye doses and long blood circulation for efficient breast cancer pulmonary metastasis imaging

Supplementary files

Article information

Article type
Paper
Submitted
07 Feb 2023
Accepted
07 May 2023
First published
10 May 2023

Biomater. Sci., 2023,11, 4644-4651

Stealth-like polysarcosine-modified nanoparticles with low dye doses and long blood circulation for efficient breast cancer pulmonary metastasis imaging

S. Chen, P. Zhou, W. Yang, D. Hu, P. Chen, P. Sun, J. Ling and Q. Fan, Biomater. Sci., 2023, 11, 4644 DOI: 10.1039/D3BM00200D

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