Issue 16, 2023

Progress in the preparation and evaluation of glucose-sensitive microneedle systems and their blood glucose regulation

Abstract

Glucose-sensitive microneedle systems (GSMSs) as an intelligent strategy for treating diabetes can well solve the problems of puncture pain, hypoglycemia, skin damage, and complications caused by the subcutaneous injection of insulin. According to the various functions of each component, herein, therapeutic GSMSs are reviewed based on three parts (glucose-sensitive models, diabetes medications, and microneedle body). Moreover, the characteristics, benefits, and drawbacks of three types of typical glucose-sensitive models (phenylboronic acid based polymer, glucose oxidase, and concanavalin A) and their drug delivery models are reviewed. In particular, phenylboronic acid-based GSMSs can provide a long-acting drug dose and controlled release rate for the treatment of diabetes. Moreover, their painless, minimally invasive puncture also greatly improves patient compliance, treatment safety, and potential application prospects.

Graphical abstract: Progress in the preparation and evaluation of glucose-sensitive microneedle systems and their blood glucose regulation

  • This article is part of the themed collection: Microneedles

Article information

Article type
Review Article
Submitted
16 Mar 2023
Accepted
14 Jun 2023
First published
03 Jul 2023

Biomater. Sci., 2023,11, 5410-5438

Progress in the preparation and evaluation of glucose-sensitive microneedle systems and their blood glucose regulation

Y. Wang, H. Yu, L. Wang, J. Hu and J. Feng, Biomater. Sci., 2023, 11, 5410 DOI: 10.1039/D3BM00463E

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