Issue 11, 2023
From the journal:

Chemical Communications

Unlike RNA-TBA (rTBA), iso-rTBA, the 2′–5′-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA†

Atish A. Wagh,ab   Vaijayanti A. Kumar,*ab   Sapna Ravindranathanbc  and  Moneesha Fernandes ORCID logo *ab  

* Corresponding authors

a Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Pune 411008, India
E-mail: va.kumar58@gmail.com, m.dcosta@ncl.res.in

b Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

c Central NMR Facility, CSIR-National Chemical Laboratory (CSIR-NCL), Pune 411008, India

Abstract

An antiparallel, functional RNA G-quadruplex of the 2′–5′-linked thrombin-binding aptamer (iso-rTBA) is reported for the first time. It can inhibit clotting and is remarkably stable to nuclease-degradation, besides having high thermal stability. It is thus, a superior candidate to TBA, rTBA or isoTBA, for further development as an anticoagulant.

Graphical abstract: Unlike RNA-TBA (rTBA), iso-rTBA, the 2′–5′-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA

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Article information

DOI
https://doi.org/10.1039/D2CC05718B
Article type
Communication
Submitted
21 Oct 2022
Accepted
13 Jan 2023
First published
13 Jan 2023

Chem. Commun., 2023,59, 1461-1464

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Unlike RNA-TBA (rTBA), iso-rTBA, the 2′–5′-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA

A. A. Wagh, V. A. Kumar, S. Ravindranathan and M. Fernandes, Chem. Commun., 2023, 59, 1461 DOI: 10.1039/D2CC05718B

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