Issue 19, 2023

Radical-mediated photoredox hydroarylation with thiosulfonate

Abstract

Herein, we report a novel visible light-induced photocatalytic system that enables intramolecular hydroarylation of unactivated alkenes. Thiosulfonate compounds were found to be the key radical precursor that mediates the Minisci-type intramolecular cyclization reaction. Under the optimal reaction conditions, a wide range of pyridyquinazolinone and pyrroloquinazolinone products were obtained in moderate to good yields.

Graphical abstract: Radical-mediated photoredox hydroarylation with thiosulfonate

Supplementary files

Article information

Article type
Communication
Submitted
03 Nov 2022
Accepted
06 Feb 2023
First published
07 Feb 2023

Chem. Commun., 2023,59, 2767-2770

Radical-mediated photoredox hydroarylation with thiosulfonate

X. Wan, D. Wang, H. Huang, G. Mao and G. Deng, Chem. Commun., 2023, 59, 2767 DOI: 10.1039/D2CC05948G

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