In situ detection of miRNA-21 in MCF-7 cell-derived extracellular vesicles using the red blood cell membrane vesicle strategy

Di Wu; Wenyue Zhang; Tao Li; Fen Li; Qingfang Feng; Xiao Cheng; Yingshu Guo

doi:10.1039/D2CC05954A

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In situ detection of miRNA-21 in MCF-7 cell-derived extracellular vesicles using the red blood cell membrane vesicle strategy†

Di Wu,^ab Wenyue Zhang,^a Tao Li,^a Fen Li,^a Qingfang Feng,^a Xiao Cheng^a and Yingshu Guo

*^a

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* Corresponding authors

^a Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China
E-mail: yingshug@126.com

^b Linyi University, Linyi, China

Abstract

In this work, we constructed a novel membrane fusion strategy for extracellular vesicles (EVs) and red blood cell membrane vesicles (RVs). A nanoscale space is formed, which can improve the efficiency of the probe reaction with miRNA-21, which allows the in situ fluorescence detection of miRNA-21 in EVs.

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DOI: https://doi.org/10.1039/D2CC05954A
Article type: Communication
Submitted: 03 Nov 2022
Accepted: 17 Jan 2023
First published: 18 Jan 2023

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Chem. Commun., 2023,59, 1987-1990

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In situ detection of miRNA-21 in MCF-7 cell-derived extracellular vesicles using the red blood cell membrane vesicle strategy

D. Wu, W. Zhang, T. Li, F. Li, Q. Feng, X. Cheng and Y. Guo, Chem. Commun., 2023, 59, 1987 DOI: 10.1039/D2CC05954A

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Chemical Communications

In situ detection of miRNA-21 in MCF-7 cell-derived extracellular vesicles using the red blood cell membrane vesicle strategy†

Abstract

Supplementary files

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In situ detection of miRNA-21 in MCF-7 cell-derived extracellular vesicles using the red blood cell membrane vesicle strategy

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