Issue 3, 2023

Rhodium(iii)-catalyzed regioselective C2-alkenylation of indoles with CF3-imidoyl sulfoxonium ylides to give multi-functionalized enamines using a migratable directing group

Abstract

A rhodium(III)-catalyzed regioselective C2-alkenylation of indoles for the construction of α-CF3 substituted enamines has been developed, which utilizes CF3-imidoyl sulfoxonium ylides (TFISYs) as alkenylating agents for the first time. A wide array of indolyl- and trifluoromethyl-decorated enamine derivatives have been assembled in moderate to good yields.

Graphical abstract: Rhodium(iii)-catalyzed regioselective C2-alkenylation of indoles with CF3-imidoyl sulfoxonium ylides to give multi-functionalized enamines using a migratable directing group

Supplementary files

Article information

Article type
Communication
Submitted
14 Nov 2022
Accepted
07 Dec 2022
First published
07 Dec 2022

Chem. Commun., 2023,59, 318-321

Rhodium(III)-catalyzed regioselective C2-alkenylation of indoles with CF3-imidoyl sulfoxonium ylides to give multi-functionalized enamines using a migratable directing group

Z. Yang, J. Tang, C. Li, Z. Chen and X. Wu, Chem. Commun., 2023, 59, 318 DOI: 10.1039/D2CC06127A

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