A dual-function probe with aggregation-induced emission feature for Cu2+ detection and chemodynamic therapy

Juan Fu; Xin Hu; Teng Guo; Weifeng Zhu; Jianwen Tian; Meiying Liu; Xiaoyong Zhang; Yen Wei

doi:10.1039/D2CC06350F

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A dual-function probe with aggregation-induced emission feature for Cu²⁺ detection and chemodynamic therapy†

Juan Fu,‡^a Xin Hu,‡^a Teng Guo,^a Weifeng Zhu,^b Jianwen Tian,^a Meiying Liu,*^ab Xiaoyong Zhang

*^a and Yen Wei

*^cd

Author affiliations

* Corresponding authors

^a Department of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China
E-mail: lmy5305@iccas.ac.cn, zhangxiaoyong@ncu.edu.cn

^b Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China

^c Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing, P. R. China
E-mail: weiyen@tsinghua.edu.cn

^d Department of Chemistry and Center for Nanotechnology and Institute of Biomedical Technology, Chung-Yuan Christian University, Chung-Li 32023, Taiwan

Abstract

Herein, a fluorescent probe (named TPACP) with aggregation-induced emission (AIE) feature was developed and utilized for the selective detection of Cu²⁺ with high sensitivity and fast-response. The resultant TPACP@Cu²⁺ complexes from coordination of TPACP with Cu²⁺ can also be potentially applied for chemodynamic and photodynamic therapy.

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Article information

DOI: https://doi.org/10.1039/D2CC06350F
Article type: Communication
Submitted: 23 Nov 2022
Accepted: 22 Mar 2023
First published: 16 May 2023

Download Citation

Chem. Commun., 2023,59, 6738-6741

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A dual-function probe with aggregation-induced emission feature for Cu²⁺ detection and chemodynamic therapy

J. Fu, X. Hu, T. Guo, W. Zhu, J. Tian, M. Liu, X. Zhang and Y. Wei, Chem. Commun., 2023, 59, 6738 DOI: 10.1039/D2CC06350F

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Chemical Communications