Issue 26, 2023
From the journal:

Chemical Communications

Non-stoichiometric carbamazepine cocrystal hydrates of 3,4-/3,5-dihydroxybenzoic acids: coformer–water exchange†

Trishna Rajbongshi,a   Kashyap Kumar Sarmah,b   Susobhan Das, ORCID logo c   Poonam Deka,a   Arijit Saha,cd   Binoy K. Saha,d   Horst Puschmann,e   C. Malla Reddy ORCID logo *c  and  Ranjit Thakuria ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Gauhati University, Guwahati, India
E-mail: ranjit.thakuria@gmail.com, ranjit.thakuria@gauhati.ac.in

b Department of Chemistry, Behali Degree College, Borgang, Biswanath, Assam, India

c Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur, India
E-mail: cmallareddy@gmail.com

d Department of Chemistry, Pondicherry University, Pondicherry, India

e OlexSys Ltd, Durham University, South Road, Durham, UK

Abstract

The cocrystallisation of carbamazepine (CBZ) with 3,4-/3,5-dihydroxybenzoic acids (34/35DHBA) with different stoichiometries formed molecular alloys, exchanging a water molecule, in their isostructural CBZ dihydrate form. Furthermore, we show a correlation between the mechanical properties of the CBZ–DHBA cocrystals with the amount of coformer present.

Graphical abstract: Non-stoichiometric carbamazepine cocrystal hydrates of 3,4-/3,5-dihydroxybenzoic acids: coformer–water exchange

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Article information

DOI
https://doi.org/10.1039/D2CC06860E
Article type
Communication
Submitted
19 Dec 2022
Accepted
06 Mar 2023
First published
07 Mar 2023

Chem. Commun., 2023,59, 3902-3905

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Non-stoichiometric carbamazepine cocrystal hydrates of 3,4-/3,5-dihydroxybenzoic acids: coformer–water exchange

T. Rajbongshi, K. K. Sarmah, S. Das, P. Deka, A. Saha, B. K. Saha, H. Puschmann, C. M. Reddy and R. Thakuria, Chem. Commun., 2023, 59, 3902 DOI: 10.1039/D2CC06860E

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