NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation

Xinzhe Yang; Keke Ding; Guiquan Zhang; Pengbo Han; Rong Hu; Zhiming Wang; Anjun Qin; Ben Zhong Tang

doi:10.1039/D2CC06932F

NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation†

Xinzhe Yang,‡^ab Keke Ding,‡^f Guiquan Zhang,^ab Pengbo Han,^ab Rong Hu,*^abe Zhiming Wang,

^ab Anjun Qin

*^ab and Ben Zhong Tang*^bcd

Author affiliations

* Corresponding authors

^a State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou, China
E-mail: msqinaj@scut.edu.cn, hurong@usc.edu.cn

^b Center for Aggregation-Induced Emission, AIE Institute, South China University of Technology, Guangzhou, China

^c School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, Guangdong, China
E-mail: tangbenz@cuhk.edu.cn

^d Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China

^e School of Chemistry and Chemical Engineering, University of South China, Hengyang, China

^f Department of Urology, The First Affiliated Hospital of Soochow University, NO. 188 Shizi Road, Suzhou, China

Abstract

A near-infrared (NIR) luminogen TST was designed and used to efficiently trigger HSP90α protein knockdown through photo-thermal conversion based on a gene interference strategy, by which in vitro and in vivo tumor ablation were significantly acquired at low-temperature.

This article is part of the themed collection: Photofunctional Materials and Transformations

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DOI: https://doi.org/10.1039/D2CC06932F
Article type: Communication
Submitted: 20 Dec 2022
Accepted: 27 Jan 2023
First published: 30 Jan 2023

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Chem. Commun., 2023,59, 2743-2746

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NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation

X. Yang, K. Ding, G. Zhang, P. Han, R. Hu, Z. Wang, A. Qin and B. Z. Tang, Chem. Commun., 2023, 59, 2743 DOI: 10.1039/D2CC06932F

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Chemical Communications

NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation†

Abstract

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NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation

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