Issue 19, 2023
From the journal:

Chemical Communications

Dihydroartemisinin engages liver fatty acid binding protein and suppresses metastatic hepatocellular carcinoma growth†

Mei-Ling Ruan,abc   Yungen Liu, ORCID logo d   Chunlei Zhang, ORCID logo bc   Xiaowen Mao,e   Di Hu,bc   Chun-Nam Lok, ORCID logo *bc   Judy Wai Ping Yam ORCID logo e  and  Chi-Ming Che ORCID logo *bcd  

* Corresponding authors

a National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan, P. R. China

b State Key Laboratory of Synthetic Chemistry, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
E-mail: cmche@hku.hk, cnlok@hku.hk

c Laboratory for Synthetic Chemistry and Chemical Biology Limited, Hong Kong Science Park, Shatin, Hong Kong, P. R. China

d Department of Chemistry, Southern University of Science and Technology, Shenzhen, Guangdong, P. R. China

e Department of Pathology, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China

Abstract

Dihydroartemisinin non-covalently binds liver fatty acid binding protein (FABP1) with micromolar affinity, acts as a FABP1-dependent peroxisome proliferator-activated receptor alpha agonist and inhibits metastatic hepatocellular carcinoma growth.

Graphical abstract: Dihydroartemisinin engages liver fatty acid binding protein and suppresses metastatic hepatocellular carcinoma growth

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D3CC00265A
Article type
Communication
Submitted
17 Jan 2023
Accepted
25 Jan 2023
First published
09 Feb 2023

Chem. Commun., 2023,59, 2747-2750

Permissions

Request permissions

Dihydroartemisinin engages liver fatty acid binding protein and suppresses metastatic hepatocellular carcinoma growth

M. Ruan, Y. Liu, C. Zhang, X. Mao, D. Hu, C. Lok, J. W. P. Yam and C. Che, Chem. Commun., 2023, 59, 2747 DOI: 10.1039/D3CC00265A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements