Issue 36, 2023
From the journal:

Chemical Communications

VITAS, a sensitive in vivo selection assay to discover enzymes producing antiviral natural products†

Aws Fahd Alharbi,a   Hayun Kim,a   Dhirish Chumroo,a   Yuxuan Ji,a   Mohammed Hakila  and  Kourosh H. Ebrahimi ORCID logo *a  

* Corresponding authors

a Institute of Pharmaceutical Science, King's College London, London, UK
E-mail: Kourosh.ebrahimi@kcl.ac.uk

Abstract

To discover new broad-spectrum antiviral nucleotide analogues from natural resources or through protein engineering, we have developed a sensitive in vivo selection assay named Viral polymerase-Inhibition Toxin-Associated Selection (VITAS). We show that the assay works with enzymes from three Kingdoms of life.

Graphical abstract: VITAS, a sensitive in vivo selection assay to discover enzymes producing antiviral natural products

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Article information

DOI
https://doi.org/10.1039/D3CC00638G
Article type
Communication
Submitted
11 Feb 2023
Accepted
11 Apr 2023
First published
11 Apr 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 5419-5422

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VITAS, a sensitive in vivo selection assay to discover enzymes producing antiviral natural products

A. F. Alharbi, H. Kim, D. Chumroo, Y. Ji, M. Hakil and K. H. Ebrahimi, Chem. Commun., 2023, 59, 5419 DOI: 10.1039/D3CC00638G

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