Copper coordination-based conjugated polymer nanoparticles for synergistic photodynamic and chemodynamic therapy

Abstract

In this work, we presented a copper coordination-based conjugated polymer nanoparticle (PPE-Cu NPs) for synergistic PDT/CDT. Upon irradiation, PPE-Cu NPs exhibited good singlet oxygen generation capability (Φ_Δ = 0.33). Meanwhile, PPE-Cu NPs were able to generate ˙OH in the presence of GSH and H₂O₂. Cellular experiments demonstrated that PPE-Cu NPs can serve as effective agents for synergistic PDT/CDT therapy.