Issue 35, 2023
From the journal:

Chemical Communications

Palladium-catalyzed intramolecular oxypalladation-initiated cascade: solvent-dependent chemodivergent approach to functionalized benzazepines and tetrahydroquinolines†

Anish Gupta, ORCID logo a   Tanvi Jandial,a   Muthu Karuppasamy,a   Nattamai Bhuvanesh,b   Subbiah Nagarajan, ORCID logo c   C. Uma Maheswari ORCID logo d  and  Vellaisamy Sridharan ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Chemical Sciences, Central University of Jammu, Rahya-Suchani (Bagla), District-Samba, Jammu, JK, India
E-mail: vesridharan@gmail.com, sridharan.che@cujammu.ac.in

b Department of Chemistry, Texas A & M University, College Station, Texas, USA

c Department of Chemistry, National Institute of Technology, Warangal, Warangal, Telangana, India

d Department of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu, India

Abstract

Palladium-catalyzed, solvent-dependent intramolecular oxypalladation-triggered domino sequences of internal alkynes bearing tethered nucleophilic carboxylic ester and electrophilic enone functionalities were developed for the chemodivergent synthesis of two completely distinct biologically significant complex molecules including isochromenone-fused benzazepines and isobenzofuranone-fused tetrahydroquinolines/chromanes in a single synthetic operation.

Graphical abstract: Palladium-catalyzed intramolecular oxypalladation-initiated cascade: solvent-dependent chemodivergent approach to functionalized benzazepines and tetrahydroquinolines

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Article information

DOI
https://doi.org/10.1039/D3CC01370G
Article type
Communication
Submitted
20 Mar 2023
Accepted
30 Mar 2023
First published
30 Mar 2023

Chem. Commun., 2023,59, 5233-5236

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Palladium-catalyzed intramolecular oxypalladation-initiated cascade: solvent-dependent chemodivergent approach to functionalized benzazepines and tetrahydroquinolines

A. Gupta, T. Jandial, M. Karuppasamy, N. Bhuvanesh, S. Nagarajan, C. U. Maheswari and V. Sridharan, Chem. Commun., 2023, 59, 5233 DOI: 10.1039/D3CC01370G

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