Nucleus-selective self-augmenting cascade nanoassemblies for targeted synergistic photo-chemo therapy of tumors

Lan Yang; Huijie Ma; Ye Liu; Rumeng Cao; Shaofeng Chen; Jiajia Wang; Ling Xiang; Jiumeng Zhang; Xuli Feng; Chenhui Wang

doi:10.1039/D3CC03331G

Nucleus-selective self-augmenting cascade nanoassemblies for targeted synergistic photo-chemo therapy of tumors†

Lan Yang,^a Huijie Ma,^a Ye Liu,^a Rumeng Cao,^a Shaofeng Chen,^a Jiajia Wang,^a Ling Xiang,^a Jiumeng Zhang,

*^a Xuli Feng

*^a and Chenhui Wang

*^a

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* Corresponding authors

^a Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China
E-mail: zhangjm@cqu.edu.cn, fengxuli@cqu.edu.cn, wangchenhui@cqu.edu.cn

Abstract

A nucleus-targeted enzyme prodrug nanocomposite, assembled from β-cyclodextrin-lysine (CL), catalase (CAT), Pt(IV) and chlorin e6 (Ce6), was developed for self-augmenting cascade photo-chemo therapy of tumors. It can effectively transport through the cytoplasm and accumulate in the nucleus, thereby significantly inhibiting tumor growth and lung metastasis.

Chemical Communications

Nucleus-selective self-augmenting cascade nanoassemblies for targeted synergistic photo-chemo therapy of tumors†

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Nucleus-selective self-augmenting cascade nanoassemblies for targeted synergistic photo-chemo therapy of tumors

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