A new dual functional H2S donor for fluorescence imaging and anti-inflammatory application

Abstract

This study explored FL-H₂S, a novel fluorescein-based H₂S donor, as an anti-inflammatory agent. The results demonstrated the efficient release of H₂S by FL-H₂S, along with its biocompatibility, real-time intracellular H₂S release and imaging capability. In vivo experiments using a rat model confirmed the anti-inflammatory effects of FL-H₂S, evidenced by reduced foot swelling. We also successfully elucidated the anti-inflammatory mechanism through ELISA and WB analysis.