Tuning of B12 photochemistry in the CarH photoreceptor to avoid radical photoproducts

Ines S. Camacho; Emma Wall; Igor V. Sazanovich; Emma Gozzard; Mike Towrie; Neil T. Hunt; Sam Hay; Alex R. Jones

doi:10.1039/D3CC03900E

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Tuning of B₁₂ photochemistry in the CarH photoreceptor to avoid radical photoproducts†

Ines S. Camacho,

^a Emma Wall,

^b Igor V. Sazanovich,

^c Emma Gozzard,^c Mike Towrie,^c Neil T. Hunt,

^d Sam Hay

^b and Alex R. Jones

*^a

Author affiliations

* Corresponding authors

^a Biometrology, Chemical and Biological Sciences Department, National Physical Laboratory, Teddington, Middlesex, UK
E-mail: alex.jones@npl.co.uk

^b Manchester Institute of Biotechnology and Department of Chemistry, The University of Manchester, 131 Princess Street, Manchester, UK

^c Central Laser Facility, STFC Rutherford Appleton Laboratory, Harwell Campus, Didcot, UK

^d Department of Chemistry and York Biomedical Research Institute, University of York, UK

Abstract

Time-resolved infrared spectroscopy reveals the flow of electron density through coenzyme B₁₂ in the light-activated, bacterial transcriptional regulator, CarH. The protein stabilises a series of charge transfer states that result in a photoresponse that avoids reactive, and potentially damaging, radical photoproducts.

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Article information

DOI: https://doi.org/10.1039/D3CC03900E
Article type: Communication
Submitted: 11 Aug 2023
Accepted: 29 Sep 2023
First published: 13 Oct 2023

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Chem. Commun., 2023,59, 13014-13017

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Tuning of B₁₂ photochemistry in the CarH photoreceptor to avoid radical photoproducts

I. S. Camacho, E. Wall, I. V. Sazanovich, E. Gozzard, M. Towrie, N. T. Hunt, S. Hay and A. R. Jones, Chem. Commun., 2023, 59, 13014 DOI: 10.1039/D3CC03900E

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