Issue 45, 2023

Investigation of the preparation, characterization, and whitening activity of co-amorphous glabridin and oxymatrine

Abstract

Glabridin (Gla) is a natural active ingredient extracted from licorice root with good whitening activity. However, its poor solubility limits its further application. Therefore, this study aimed to develop a novel co-amorphous Gla–OMT raw material using oxymatrine (OMT) as a co-former, aiming to improve its physicochemical properties and enhance its whitening activity. Firstly, the formation of co-amorphous Gla–OMT was confirmed by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC). Subsequently, FT-IR, NMR, and molecular dynamics simulations were used to investigate the interaction between the co-amorphous Gla–OMT molecules, and solubility experiments and supersaturation dissolution experiments were used to investigate the solubilization of the co-amorphous Gla–OMT. In addition, the in vitro release mechanism of the co-amorphous Gla–OMT was investigated using a Franz diffusion cell and its biosafety and whitening activity were evaluated using cell experiments. In conclusion, the successful preparation of co-amorphous Gla–OMT and the evaluation of its whitening activity in this study have significant implications for guiding the development and application of whitening products in the future.

Graphical abstract: Investigation of the preparation, characterization, and whitening activity of co-amorphous glabridin and oxymatrine

Supplementary files

Article information

Article type
Paper
Submitted
13 Aug 2023
Accepted
20 Sep 2023
First published
26 Sep 2023

CrystEngComm, 2023,25, 6252-6265

Investigation of the preparation, characterization, and whitening activity of co-amorphous glabridin and oxymatrine

P. Liang, Y. Hu, Z. Wang, Y. Guo, H. Chen, C. Jiang, Q. Zeng, C. Shen, Y. Wu, L. Liu, Y. Yi, H. Zhu, Z. Yang and Q. Liu, CrystEngComm, 2023, 25, 6252 DOI: 10.1039/D3CE00807J

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