Best practice for sampling in automated parallel synthesizers

Abstract

The ongoing digitalization leads to a higher degree of automation in chemical and material research. Particularly important is the sampling of reactions in order to monitor reaction kinetics and to enable online- and offline characterization. The sampling process must be well designed to take full advantage of the automated method without compromising analytical results compared to manual sampling. We present a new method for taking samples in an automated fashion for the application in synthesis robots and liquid handling robots obtained by simple additive manufacturing of a vial holder. This new method is systematically compared to standard approaches, which are currently the state-of-the-art techniques. The major benefit of the new technology is particularly important for easily evaporable solvents.