The bulk solvent-free synthesis of cyclopropanes via a ball-milling-enabled Simmons–Smith reaction is herein described. Harnessing the use of mechanochemical techniques to activate zinc(0), this, all under air and operationally simple protocol, allows the synthesis of a wide range of cyclopropane structures and scale up to enable gram-scale.
L. Pontini, J. A. Leitch and D. L. Browne, Green Chem., 2023, 25, 4319 DOI: 10.1039/D3GC00649B
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