Issue 3, 2023
From the journal:

Nanoscale Advances

Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model†

Fang Liu,‡a   Yingzhi Luo,‡b   Huan Chen,a   Shengjing Xu,c   Dongyan Zhang,c   Hong Sang,*a   Chenjie Xu ORCID logo *d  and  Min Zhang*c  

* Corresponding authors

a Department of Dermatology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China
E-mail: sanghong@nju.edu.cn

b Department of Dermatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China

c Department of Dermatology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, China
E-mail: zhangmin76ch@163.com

d Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, China
E-mail: chenjie.xu@cityu.edu.hk

Abstract

Microneedle technology can effectively suppress the formation of hypertrophic scarring in both animals and humans. Our previous research has revealed that this is due to the physical contact inhibition effect by using microneedles made of liquid-crystal polymers as the model device. One important factor we didn't study is the influence of the fabrication materials of microneedles. Therefore, this article examines this key point on a rabbit ear hypertrophic scar model. We monitor the thickness of the scars, and the expression of α-SMA and Ki-67 protein, and TGF-β1 mRNA in a period of 42 days. Among microneedles made of 6 polymeric materials and stainless steel, polymethylmethacrylate microneedles present superiority in all aspects including the reduction of tissue fibrosis, and the expression of α-SMA, Ki-67 protein and TGF-β1 mRNA. On the other hand, polycarbonates, polyurethane, and polylactic-co-glycolic acid microneedles could suppress three biomarker expressions.

Graphical abstract: Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

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Article information

DOI
https://doi.org/10.1039/D2NA00604A
Article type
Paper
Submitted
06 Sep 2022
Accepted
16 Dec 2022
First published
23 Dec 2022
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2023,5, 927-933

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Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

F. Liu, Y. Luo, H. Chen, S. Xu, D. Zhang, H. Sang, C. Xu and M. Zhang, Nanoscale Adv., 2023, 5, 927 DOI: 10.1039/D2NA00604A

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