Issue 4, 2023

Copper nano-architecture topical cream for the accelerated recovery of burnt skin

Abstract

Skin burns are debilitating injuries with significant morbidity and mortality associated with infections and sepsis, particularly in immunocompromised patients. In this context, nanotechnology can provide pioneering approaches for the topical treatment of burnt skin. Herein, the significant recovery of radiation-damaged skin by exploiting copper ultrasmall-in-nano architectures (CuNAs) dispersed in a home-made cosmetic cream is described and compared to other noble metals (such as gold). Owing to their peculiar design and components, CuNAs elicit a substantial recovery from burned skin in in vivo models after one topical application, and a significant anti-inflammatory effect is highlighted by reducing cytokine expression. The treatment exhibited neither significant toxicity nor the alteration of copper metabolism in the target organs because of the CuNA biocompatibility. This study may open new horizons in the treatment of radiation dermatitis and skin burns caused by other external events.

Graphical abstract: Copper nano-architecture topical cream for the accelerated recovery of burnt skin

Supplementary files

Article information

Article type
Paper
Submitted
07 Nov 2022
Accepted
17 Jan 2023
First published
18 Jan 2023
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2023,5, 1212-1219

Copper nano-architecture topical cream for the accelerated recovery of burnt skin

M. L. Ermini, M. Summa, A. Zamborlin, V. Frusca, A. K. Mapanao, E. Mugnaioli, R. Bertorelli and V. Voliani, Nanoscale Adv., 2023, 5, 1212 DOI: 10.1039/D2NA00786J

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