Issue 23, 2023

Ex vivo transdermal delivery of 3H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

Abstract

Inherent barrier properties of the skin impose significant challenges to the transdermal delivery of drugs to systemic circulation. Here, the ex vivo transdermal permeation and deposition of an anti-malarial prophylactic atovaquone solid drug nanoformulation is radiometrically evaluated following application of a solid microneedle format.

Graphical abstract: Ex vivo transdermal delivery of 3H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

Supplementary files

Article information

Article type
Communication
Submitted
26 Jun 2023
Accepted
11 Oct 2023
First published
17 Oct 2023
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2023,5, 6400-6404

Ex vivo transdermal delivery of 3H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

S. Morris, M. Long, A. Savage, A. Owen, S. Rannard and H. Cauldbeck, Nanoscale Adv., 2023, 5, 6400 DOI: 10.1039/D3NA00454F

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