Issue 3, 2023
From the journal:

New Journal of Chemistry

Isolation of cytotoxic daphnane-type and tigliane-type diterpenoids from Daphne genkwa using MetGem software†

Si-Hui Mi,‡a   Zhi-Kang Duan,‡a   Yu-Jue Wang,a   Shu-Hui Dong,a   Peng Zhao,a   Guo-Dong Yao,a   Qing-Bo Liu,a   Bin Lin,b   Shao-Jiang Song ORCID logo a  and  Xiao-Xiao Huang ORCID logo *a  

* Corresponding authors

a Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning, China
E-mail: xiaoxiao270@163.com

b School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, China

Abstract

To discover diterpenoids that naturally possess chemical weapons against cancer, the biological and chemical diversity of the flower buds of Daphne genkwa Sieb. et Zucc was investigated. Guided by LC-MS/MS analysis and the MetGem Molecular Networking, eight daphnane-type and tigliane-type diterpenoids including four new compounds were isolated. Spectroscopic elucidation and ECD quantum chemical calculations revealed their structures. All compounds were evaluated their cytotoxic activity of A549, Hep3B, and MCF-7 cell lines. Compounds 1 and 8 showed potent activity against the A549 and Hep3B cells.

Graphical abstract: Isolation of cytotoxic daphnane-type and tigliane-type diterpenoids from Daphne genkwa using MetGem software

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Article information

DOI
https://doi.org/10.1039/D2NJ05276H
Article type
Paper
Submitted
28 Oct 2022
Accepted
07 Dec 2022
First published
08 Dec 2022

New J. Chem., 2023,47, 1517-1524

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Isolation of cytotoxic daphnane-type and tigliane-type diterpenoids from Daphne genkwa using MetGem software

S. Mi, Z. Duan, Y. Wang, S. Dong, P. Zhao, G. Yao, Q. Liu, B. Lin, S. Song and X. Huang, New J. Chem., 2023, 47, 1517 DOI: 10.1039/D2NJ05276H

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