Photo-promoted cascade cyclization of aryl alkynes: access to thiocyanate/trifluoromethylthio-containing quinolino[2,1-b]quinazolinones

Abstract

Photo-promoted cascade cyclization of aryl alkynes with NH₄SCN has been reported for the construction of diverse SCN-containing quinolino[2,1-b]quinazolinones. SCF₃-containing fused cyclic compounds could also be obtained with high yields. In addition, a variety of scaled-up reactions, transformation operations, radical inhibition experiments, and on/off light studies were undertaken to support the merits and reaction mechanism of this tandem system. Finally, we confirmed the skeleton of the desired product via single-crystal X-ray diffraction.