Catalyst-free electrochemical trifluoromethylation of coumarins using CF3SO2NHNHBoc as the CF3 source

Abstract

An efficient electrochemical trifluoromethylation of coumarins using CF₃SO₂NHNHBoc as the source of the trifluoromethyl group was developed. Under catalyst-free and external oxidant-free electrolysis conditions, a range of 3-trifluoromethyl coumarins were obtained in moderate to good yields. The method could be easily scaled up with moderate efficiency.