Diyne-steered switchable regioselectivity in cobalt(ii)-catalysed C(sp2)–H activation of amides with unsymmetrical 1,3-diynes†
Prakriti
Dhillon, 
a
Prasad
Anaspure,
a
Jesper G.
Wiklander,
a
Subban
Kathiravan
a
and
Ian A.
Nicholls
*a
a
Prasad
Anaspure,
a
Jesper G.
Wiklander,
a
Subban
Kathiravan
a
and
Ian A.
Nicholls
*a
Abstract
The regiochemical outcome of a cobalt(II) catalysed C–H activation reaction of aminoquinoline benzamides with unsymmetrical 1,3-diynes under relatively mild reaction conditions can be steered through the choice of diyne. The choice of diyne provides access to either 3- or 4-hydroxyalkyl isoquinolinones, paving the way for the synthesis of more highly elaborate isoquinolines.
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