Issue 35, 2023

Transition metal-catalyzed reactivity of carbenes with boronic acid derivatives for arylation (alkylation) and beyond

Abstract

This comprehensive review article discussed the reactivity of carbenes with boronic acid derivatives for the one-pot synthesis of diarylmethanes, difluoromethylated arenes, aryl and alkyl boron compounds, arylacetic acid derivatives, furan derivatives, and many other compounds. We have summarized the arylation, vinylation, and alkylation of carbenes utilizing various transition metals, viz. palladium, rhodium, copper, and platinum, for the construction of carbon–carbon bonds, carbon–boron bonds, and beyond through the cross-coupling strategy. The reason for the increasing popularity of these novel methodologies is their application in the synthesis and late-stage functionalization of biologically active compounds and natural products. Notably, organoboron compounds are exemplified as versatile synthetic intermediates for constructing various bonds.

Graphical abstract: Transition metal-catalyzed reactivity of carbenes with boronic acid derivatives for arylation (alkylation) and beyond

Article information

Article type
Review Article
Submitted
07 Jun 2023
Accepted
11 Aug 2023
First published
14 Aug 2023

Org. Biomol. Chem., 2023,21, 7062-7078

Transition metal-catalyzed reactivity of carbenes with boronic acid derivatives for arylation (alkylation) and beyond

A. Babbar, P. Yamini, M. Saleem and D. Yadagiri, Org. Biomol. Chem., 2023, 21, 7062 DOI: 10.1039/D3OB00904A

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