Electrochemical trifluoroalkylation/annulation for the synthesis of CF3-functionalized tetrahydroquinolines and dihydroquinolinones

Abstract

Tuning the electronic structure of protecting groups on the nitrogen atom of substrates has emerged as an effective strategy to achieve the tandem trifluoromethylation/C(sp²)–H annulation using Langlois’ reagent as the CF₃ source for the electrochemical synthesis of functionalized tetrahydroquinolines and dihydroquinolinones.