A practical synthesis of new β-difluoromethoxy vinyl sulfones has been explored by O-difluoromethylation of β-ketosulfones using the inexpensive and easily workable sodium chlorodifluoroacetate as a difluorocarbene precursor. The strategy is convenient and regioselective, and features an adequate substrate scope and functional group tolerance.
K. Ishu, N. S. Prabhakar and K. N. Singh, Org. Biomol. Chem., 2023, 21, 6588 DOI: 10.1039/D3OB01142A
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