Issue 42, 2023
From the journal:

Organic & Biomolecular Chemistry

Highly regio- and stereocontrolled preparation of α-(trifluoromethyl)-β-(phenylthio) enamines by the hydroamination of in situ-synthesized 1-(trifluoromethyl)-2-(phenylthio)ethyne†

Akihiro Koga,a   Maki Matsuda,a   Rin Tanaka,a   Minami Endo,a   Yasunori Yamadaa  and  Takeshi Hanamoto ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Applied Chemistry, Saga University, Honjyo-machi 1, Saga 840-8502, Japan
E-mail: hanamoto@cc.saga-u.ac.jp

Abstract

Various nitrogen nucleophiles were easily added to in situ-generated 1-(trifluoromethyl)-2-(phenylthio)ethyne to afford the corresponding trifluoromethyl enamines in good-to-high yields and with high regio- and stereocontrol under very mild conditions.

Graphical abstract: Highly regio- and stereocontrolled preparation of α-(trifluoromethyl)-β-(phenylthio) enamines by the hydroamination of in situ-synthesized 1-(trifluoromethyl)-2-(phenylthio)ethyne

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D3OB01473H
Article type
Paper
Submitted
14 Sep 2023
Accepted
07 Oct 2023
First published
16 Oct 2023

Org. Biomol. Chem., 2023,21, 8528-8534

Permissions

Request permissions

Highly regio- and stereocontrolled preparation of α-(trifluoromethyl)-β-(phenylthio) enamines by the hydroamination of in situ-synthesized 1-(trifluoromethyl)-2-(phenylthio)ethyne

A. Koga, M. Matsuda, R. Tanaka, M. Endo, Y. Yamada and T. Hanamoto, Org. Biomol. Chem., 2023, 21, 8528 DOI: 10.1039/D3OB01473H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements