Copper-catalysed α-functionalization of ketones with nucleophiles: universal and efficient access to nafimidone derivatives

Abstract

Herein, we report our discovery of a convenient and efficient approach to construct various C–X bonds using a copper catalytic system. This strategy features mild reaction conditions and easy formation of various C–X bonds (C–O, C–Cl, C–Br, C–I, C–F and C–S). Such a methodology successfully provides a universal and practical approach for the synthesis of potentially bioactive nafimidone derivatives, and enriches the present library of compounds for medicinal screening purposes.