Issue 3, 2023

A novel isocyanide/Ag2CO3-promoted addition of heteroatoms to alkynes under mild conditions

Abstract

A facile and practical isocyanide/Ag2CO3-promoted atom-economic addition of heteroatoms to alkynes has been developed for the construction of high-value scaffolds. In contrast to the reported methods, this strategy featured efficient and green characteristics, e.g., broad functional group compatibility, rapid and quantitative conversion, use of an eco-friendly solvent (EtOH), and an isocyanide/Ag2CO3 catalytic transformation. Moreover, the catalyst loading of Ag2CO3 could be decreased to 1 mol% with the aid of isocyanide. Therefore, in principle, numerous common classes of additions of a nucleophilic element-hydrogen to alkynes could likewise be amenable to this catalyst system.

Graphical abstract: A novel isocyanide/Ag2CO3-promoted addition of heteroatoms to alkynes under mild conditions

Supplementary files

Article information

Article type
Research Article
Submitted
19 Oct 2022
Accepted
30 Nov 2022
First published
23 Dec 2022

Org. Chem. Front., 2023,10, 786-792

A novel isocyanide/Ag2CO3-promoted addition of heteroatoms to alkynes under mild conditions

J. Lei, J. Xu, Y. Luo, J. Li, J. Wang, H. Li, Z. Xu and Z. Chen, Org. Chem. Front., 2023, 10, 786 DOI: 10.1039/D2QO01642G

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