Issue 4, 2023

A general protocol for stereoselective construction of enaminyl sulfonyl fluorides

Abstract

A simple, efficient, and mild reaction of 2-chloroprop-2-ene-1-sulfonyl fluoride (CESF) with amines was developed, affording a variety of highly functionalized enaminyl sulfonyl fluorides in good to excellent yields (56–96%). This transformation features a broad substrate scope, high atom economy, operational simplicity and up to 100% stereoselectivity, which can provide great application value in medicinal chemistry, chemical biology, and drug discovery.

Graphical abstract: A general protocol for stereoselective construction of enaminyl sulfonyl fluorides

Supplementary files

Article information

Article type
Research Article
Submitted
12 Nov 2022
Accepted
31 Dec 2022
First published
03 Jan 2023

Org. Chem. Front., 2023,10, 951-956

A general protocol for stereoselective construction of enaminyl sulfonyl fluorides

L. Chen, K. P. Rakesh and H. Qin, Org. Chem. Front., 2023, 10, 951 DOI: 10.1039/D2QO01810A

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