Electrochemical oxidative radical cascade reactions for the synthesis of difluoromethylated benzoxazines

Abstract

Benzoxazines are important structures in pharmaceuticals and functional molecules. We herein describe an electrochemical oxidative strategy for the synthesis of benzoxazines without transition-metal catalysts and external oxidants. In a undivided cell, a series of olefinic amides can be transferred to difluoromethylated benzoxazines with up to 87% yield via oxydifluoromethylation with CF₂HSO₂Na as the difluoromethylation reagent.