Issue 18, 2023

Transition-metal-free chemoselective reduction of α,β-unsaturated ketones using H2O as a hydrogen source

Abstract

A metal-free chemoselective reduction of α,β-unsaturated carbonyl compounds using water as a hydrogen donor is described. Various functional groups attached to substrates were well tolerated to afford the corresponding products in moderate to good yields under simple reaction conditions. This reaction has great potential to be a general and practical reduction methodology in organic transformation.

Graphical abstract: Transition-metal-free chemoselective reduction of α,β-unsaturated ketones using H2O as a hydrogen source

Supplementary files

Article information

Article type
Research Article
Submitted
25 Jun 2023
Accepted
11 Aug 2023
First published
11 Aug 2023

Org. Chem. Front., 2023,10, 4703-4708

Transition-metal-free chemoselective reduction of α,β-unsaturated ketones using H2O as a hydrogen source

E. Yu, G. Mao, G. Deng and F. Xiao, Org. Chem. Front., 2023, 10, 4703 DOI: 10.1039/D3QO00963G

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