Issue 9, 2023, Issue in Progress

Morphological, cytotoxicity, and coagulation assessments of perlite as a new hemostatic biomaterial

Abstract

Hemorrhage control is vital for clinical outcomes after surgical treatment and pre-hospital trauma injuries. Numerous biomaterials have been investigated to control surgical and traumatic bleeding. In this study, for the first time, perlite was introduced as an aluminosilicate biomaterial and compared with other ceramics such as kaolin and bentonite in terms of morphology, cytotoxicity, mutagenicity, and hemostatic evaluations. Cellular studies showed that perlite has excellent viability, good cell adhesion, and high anti-mutagenicity. Coagulation results demonstrated that the shortest clotting time (140 seconds with a concentration of 50 mg mL−1) was obtained for perlite samples compared to other samples. Therefore, perlite seems most efficient as a biocompatible ceramic for hemorrhage control and other biomaterial designs.

Graphical abstract: Morphological, cytotoxicity, and coagulation assessments of perlite as a new hemostatic biomaterial

Article information

Article type
Paper
Submitted
07 Dec 2022
Accepted
13 Feb 2023
First published
21 Feb 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 6171-6180

Morphological, cytotoxicity, and coagulation assessments of perlite as a new hemostatic biomaterial

E. Biazar, S. Heidari Keshel, V. Niazi, N. Vazifeh Shiran, R. Saljooghi, M. Jarrahi and A. Mehdipour Arbastan, RSC Adv., 2023, 13, 6171 DOI: 10.1039/D2RA07795G

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