Issue 5, 2023
From the journal:

RSC Advances

Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

Munirah M. Al-Rooqi,a   Ehsan Ullah Mughal, ORCID logo *b   Qandeel Alam Raja,b   Essam M. Hussein,ac   Nafeesa Naeem, ORCID logo b   Amina Sadiq,d   Basim H. Asghar,a   Ziad Moussa ORCID logo e  and  Saleh A. Ahmed ORCID logo *ac  

* Corresponding authors

a Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, 21955 Makkah, Saudi Arabia
E-mail: saahmed@uqu.edu.sa

b Department of Chemistry, University of Gujrat, Gujrat-50700, Pakistan
E-mail: ehsan.ullah@uog.edu.pk

c Chemistry Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt

d Department of Chemistry, Government College Women University, Sialkot-51300, Pakistan

e Department of Chemistry, College of Science, United Arab Emirates University, P.O. Box 15551, Al Ain, Abu Dhabi, United Arab Emirates

Abstract

Infections caused by bacteria are a significant issue on a global scale, and imperative action is required to discover novel or improved therapeutic agents. Flavonoids are a class of plant-derived compounds that have a variety of potentially useful bioactivities. These activities include immediate antimicrobial properties, synergistic effect with antimicrobials, ferocious repression of pathogenicity, anti-urease activity etc. This review summarizes current studies concerning anti-urease actions of flavonoids as well as structural–activity correlation investigations of the flavonoid core structure. It is possible that if researchers investigate the many structural changes that may be made in flavonoid rings, they'll be able to build up novel compounds that have powerful and effective anti-urease properties.

Graphical abstract: Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

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Article information

DOI
https://doi.org/10.1039/D2RA08284E
Article type
Review Article
Submitted
28 Dec 2022
Accepted
16 Jan 2023
First published
23 Jan 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 3210-3233

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Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

M. M. Al-Rooqi, E. U. Mughal, Q. A. Raja, E. M. Hussein, N. Naeem, A. Sadiq, B. H. Asghar, Z. Moussa and S. A. Ahmed, RSC Adv., 2023, 13, 3210 DOI: 10.1039/D2RA08284E

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