Here we present an iridium catalysed C2-selective methylation of indoles using methyltrifluoroborate as a source of methyl group. The iridium catalyst selectively discriminates the indole C2 and C4 C–H bonds by coordination with a pivaloyl directing group.
S. Kathiravan, T. Zhang and I. A. Nicholls, RSC Adv., 2023, 13, 11291 DOI: 10.1039/D3RA02031B
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