Issue 41, 2023, Issue in Progress

Magnetic nanoparticles modified with a copper(i) complex as a novel and efficient reusable catalyst for A3 coupling leading to C–N bond formation

Abstract

Propargylamines are an important and valuable family of nitrogen-containing compounds with many applications in the fields of medical, industrial, and chemical processes. One-pot multicomponent A3 coupling reactions of aldehydes, amines, and alkynes in the presence of transition metals as catalysts is an efficient strategy for preparing propargylamines. In this study, we fabricated a novel magnetically reusable copper nanocatalyst [Fe3O4–BIm–Pyrim–CuI] through the immobilization of the copper(I) complex on the surface of the magnetic nanoparticles modified with benzimidazole–pyrimidine ligand and evaluated its catalytic activity in the preparation of propargylamines through one-pot multicomponent A3 coupling reactions of aldehydes, amines, and alkynes. Under this catalytic system, aryl substrates with both electron-donating and electron-withdrawing substituents also gave the desired products in excellent yields under standardized conditions. The Fe3O4–BIm–Pyrim–CuI catalyst was easily separated using an external magnet, and the recovered catalyst was reused in 8 cycles without significant loss of activity.

Graphical abstract: Magnetic nanoparticles modified with a copper(i) complex as a novel and efficient reusable catalyst for A3 coupling leading to C–N bond formation

Supplementary files

Article information

Article type
Paper
Submitted
19 Jul 2023
Accepted
21 Sep 2023
First published
03 Oct 2023
This article is Open Access
Creative Commons BY license

RSC Adv., 2023,13, 28964-28974

Magnetic nanoparticles modified with a copper(I) complex as a novel and efficient reusable catalyst for A3 coupling leading to C–N bond formation

W. Li, J. Yan, W. Xu and L. Y. Zhang, RSC Adv., 2023, 13, 28964 DOI: 10.1039/D3RA04871C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements