Issue 43, 2023
From the journal:

Chemical Science

Micellar catalysis: a green solution to enable undirected and mild C–H activation of (oligo)thiophenes at the challenging β-position†

Pascal Hauk,a   Valérie Mazan, ORCID logo a   Fabrice Gallou ORCID logo *b  and  Joanna Wencel-Delord ORCID logo *a  

* Corresponding authors

a Laboratoire d'Innovation Moléculaire et Applications (UMR CNRS 7042), Université de Strasbourg, Université de Haute Alsace, ECPM, 67087 Strasbourg, France
E-mail: wenceldelord@unistra.fr

b Chemical & Analytical Development, Novartis Pharma AG, 4056 Basel, Switzerland
E-mail: fabrice.gallou@novartis.com

Abstract

The unexpected potential of micellar medium to achieve challenging β-selective direct arylation of (oligo)thiophenes is reported. Thanks to the use of a water/surfactant solution in combination with natural feedstock-derived undecanoic acid as an additive, this high-yielding C–H coupling could be performed regioselectively at room temperature.

Graphical abstract: Micellar catalysis: a green solution to enable undirected and mild C–H activation of (oligo)thiophenes at the challenging β-position

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Article information

DOI
https://doi.org/10.1039/D3SC03708H
Article type
Edge Article
Submitted
19 Jul 2023
Accepted
04 Oct 2023
First published
05 Oct 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2023,14, 12049-12055

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Micellar catalysis: a green solution to enable undirected and mild C–H activation of (oligo)thiophenes at the challenging β-position

P. Hauk, V. Mazan, F. Gallou and J. Wencel-Delord, Chem. Sci., 2023, 14, 12049 DOI: 10.1039/D3SC03708H

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