In situ setup for screening of drug permeation by NMR spectroscopy

Malte Mildner; Simon Hanio; Sebastian Endres; Lena Scheller; Bettina Engel; Laura Castañar; Lorenz Meinel; Ann-Christin Pöppler

doi:10.1039/D3AY01995K

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In situ setup for screening of drug permeation by NMR spectroscopy†

Malte Mildner,‡^a Simon Hanio,

‡^b Sebastian Endres,^a Lena Scheller,

^b Bettina Engel,^b Laura Castañar,

^c Lorenz Meinel

^b and Ann-Christin Pöppler

*^a

Author affiliations

* Corresponding authors

^a Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany
E-mail: ann-christin.poeppler@uni-wuerzburg.de

^b Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany

^c Department of Organic Chemistry, Faculty of Chemical Science, Complutense University of Madrid, Madrid, Spain

Abstract

There are various commercially available setups for studying drug permeation, which differ in cost and manual labor. We explore an artificial membrane in an NMR tube to assess drug permeation with automated measurements. NMR-based concentrations were validated with HPLC and compared to a conventional setup. Setup-specific challenges and workarounds as well as future setup-designs for this and other applications are discussed.

This article is part of the themed collection: Analytical Methods HOT Articles 2024

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Article information

DOI: https://doi.org/10.1039/D3AY01995K
Article type: Communication
Submitted: 11 Nov 2023
Accepted: 30 Dec 2023
First published: 08 Jan 2024

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Anal. Methods, 2024,16, 1468-1472

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In situ setup for screening of drug permeation by NMR spectroscopy

M. Mildner, S. Hanio, S. Endres, L. Scheller, B. Engel, L. Castañar, L. Meinel and A. Pöppler, Anal. Methods, 2024, 16, 1468 DOI: 10.1039/D3AY01995K

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Analytical Methods

In situ setup for screening of drug permeation by NMR spectroscopy†

Abstract

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In situ setup for screening of drug permeation by NMR spectroscopy

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