Issue 11, 2024
From the journal:

Chemical Communications

Malachite green: a long-buried water-soluble AIEgen with near-infrared fluorescence for living cell nucleus staining†

Yuan Luo,‡a   Lihua Zhou, ORCID logo ‡b   Lili Du,‡c   Yangzi Xie,a   Xiang-Yang Lou,d   Lintao Cai, ORCID logo a   Ben Zhong Tang,e   Ping Gong*a  and  Pengfei Zhang ORCID logo *a  

* Corresponding authors

a Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China
E-mail: ping.gong@siat.ac.cn, pf.zhang@siat.ac.cn

b School of Applied Biology, Shenzhen Institute of Technology, No. 1 Jiangjunmao, Shenzhen, P. R. China

c School of Life Sciences, Jiangsu University, Zhenjiang, P. R. China

d GTS-UAB Research Group, Department of Chemistry, Facultat de Ciències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain

e School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong 518172, China

Abstract

Fluorescent imaging probes are crucial for exploring nucleus-related cellular events in live cells. Ideal probes should be photostable, small-sized, highly contrasted, and low in background. Here, we discovered that malachite green is a water-soluble near-infrared luminogen with aggregation-induced emission properties. Importantly, it can be used for living cell nucleus staining in a wash-free manner.

Graphical abstract: Malachite green: a long-buried water-soluble AIEgen with near-infrared fluorescence for living cell nucleus staining

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Article information

DOI
https://doi.org/10.1039/D3CC05535C
Article type
Communication
Submitted
10 Nov 2023
Accepted
30 Dec 2023
First published
02 Jan 2024

Chem. Commun., 2024,60, 1452-1455

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Malachite green: a long-buried water-soluble AIEgen with near-infrared fluorescence for living cell nucleus staining

Y. Luo, L. Zhou, L. Du, Y. Xie, X. Lou, L. Cai, B. Z. Tang, P. Gong and P. Zhang, Chem. Commun., 2024, 60, 1452 DOI: 10.1039/D3CC05535C

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