One-pot C–N/C–C bond formation and oxidation of donor–acceptor cyclopropanes with tetrahydroisoquinolines: access to benzo-fused indolizines

Abstract

One-pot C–N/C–C bond formation of donor–acceptor cyclopropanes (DACs) with tetrahydroisoquinolines (THIQs) has been achieved to furnish benzo-fused indolizines. These reactions involve a MgI₂-catalyzed ring opening of DACs and oxidative annulation using Mn(OAc)₃·2H₂O. The substrate scope and functional group diversity are the important practical features.