An activated near-infrared mitochondrion-targetable fluorescent probe for rapid detection of NADH

Yaxin Sun; Yanyun Mao; Tianwen Bai; Tianqing Ye; Yanfei Lin; Fang Wang; Lei Li; Longhua Guo; Haiying Liu; Jianbo Wang

doi:10.1039/D4CC01378F

An activated near-infrared mitochondrion-targetable fluorescent probe for rapid detection of NADH†

Yaxin Sun,^a Yanyun Mao,^b Tianwen Bai,^b Tianqing Ye,^b Yanfei Lin,^b Fang Wang,

^a Lei Li,^b Longhua Guo,

*^b Haiying Liu

*^c and Jianbo Wang

*^b

Author affiliations

* Corresponding authors

^a College of Pharmacy, Zhejiang University of Technology, Hangzhou, China

^b Jiaxing Key Laboratory of Molecular Recognition and Sensing, College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China
E-mail: guolh@zjxu.edu.cn, wjb4207@mail.ustc.edu.cn

^c Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA
E-mail: hyliu@mtu.edu

Abstract

A novel NIR fluorescent probe based on quinoline-conjugated benzo[cd]indol dual-salt for NADH was developed. This probe swiftly detects and responds sensitively to both endogenous and exogenous NADH alterations, enabling imaging of NADH fluctuations in type II diabetic and AD model cells.

Chemical Communications

An activated near-infrared mitochondrion-targetable fluorescent probe for rapid detection of NADH†

Abstract

Supplementary files

Article information

Download Citation

Permissions

An activated near-infrared mitochondrion-targetable fluorescent probe for rapid detection of NADH

Social activity

Search articles by author

Spotlight

Advertisements